This page has been created to allow support, critique, discussion and debate over the existence or non-existence of Undermethylation. Join in on our facebook page discussions. Feel free to include the scientific versus the anecdotal, the personal versus the professional.
HOW OTHER GENETIC MUTATIONS MIGHT BE AFFECTING YOU?
Before you start diving in to find out whether you have a MTHFR mutation, it is important to know that there are many variations of this mutation and numerous complexities to how this mutation affects other processes in the body. There are also a variety of ways that you may respond to taking 5MTHF.
There are actually two main possible MTHFR mutations, C677T and A1298C, and depending on whether you have either or both, on one or both strands of your DNA, will determine the extent to which the enzyme is affected.
Then, to make it more complex, there are cofactor nutrients involved in methylation, including B6, B12 and magnesium, so it is not just about folate.
Plus, if your body is not changing folic acid into folate well, it could be disrupting other nutrients and processes, including the production of neurotransmitters, detoxification of estrogen, and production of glutathione (an important anti-oxidant). This can result in anxiousness, fatigue, brain fog, as well as increased risk of cancers, heart disease, Alzheimer’s disease, and diabetes. But it also means we need to proceed carefully when we start giving methylfolate, because all of these processes will be affected.
Furthermore, there are other possible mutations that can affect and be affected by MTHFR. So it really helps to have a practitioner guide you through the information.
In summary, adequate folate intake is necessary in pregnancy, but its dose and form needs to be well controlled. Excessive folic acid intake is confirmed to cause higher risks of allergy, cognition disorders, cancer, diabetes, higher rates of autism and other health issues in both pregnant women and their babies. So for those with mutations in the folate pathway like Folate Receptor 2 genes, MTHFD1, MTHFD1L, MTHFS, and MTHFR and in the B12 genes MTR and MTRR we are much safer using either folinic or L-5MTHF. L-5MTHF particularly as it’s a natural form of folate and its risk of overdose is much lower than folic acid for pregnant women.
The MTHFR gene provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is important for a chemical reaction involving forms of the vitamin folate (also called vitamin B9). Specifically, this enzyme converts a molecule called 5,10-methylenetetrahydrofolate to a molecule called 5-methyltetrahydrofolate. This reaction is required for the multistep process that converts the amino acid homocysteine to another amino acid, methionine. The body uses methionine to make proteins and other important compounds.
Source: Wellness Mama
Methyl groups control:
The stress (fight-or-flight) response
The production and recycling of glutathione — the body's master antioxidant
The detoxification of hormones, chemicals and heavy metals
The inflammation response
Genetic expression and the repair of DNA
Neurotransmitters and the balancing of brain chemistry
The repair of cells damaged by free radicals
The immune response, controlling T-cell production, fighting infections and viruses and regulating the immune response
#methylation #undermethylation #biochemistry #health #wellness #fitness #healthy #lifestyle #dna #energy #hormones #immunesystem #detox #detoxification #mood #psychology #mentalhealth #instahealth #alternativehealth #alternativemedicine #complementaryhealth #complementarymedicine
"Being healthy isn't a goal, we are always in a state of flux. Being healthy is about balance and is a way of living."
Health tip #1/6: BREATHING & THOUGHTS
We often, subconsciously, focus on what we don’t want rather than what we do want. All stress is in the eye of the beholder so question what causes you stress and see if you can be the mechanic of your mind and fix the cause.
Meditation, tai chi, qi gong, yoga, floatation therapy, massage, getting a manicure, listening to your favourite music, spending time in nature, drawing, painting, playing music, hugging, laughing and playing are all ways you can move from a stressful (sympathetic nervous system) state to a more relaxed (parasympathetic nervous system) state.
#taichi #qigong #qi #yin #meditate #meditation #play #love #laugh #sing #dance #paint #draw #art
Overmethylation vs undermethylation? Whaat? Here is an actual case study of how fast one can feel up and then down and up, down. Effect can seriously and easily occur when working with powerful nutrients such as methyl donors - especially when combined with medications.
So you’re taking all these supplements, but are you getting enough sleep? Drinking enough filtered water? Eating a wholesome diet? Getting enough exercise and chill time? Our modern way of life affects your requirement to methylate.
There is a huge array of cellular damage from our toxic environment which damages cellular function. Mobile phones, planes, radiation, water pollutants, industrial wastes, pesticides, chemicals, plastics, radiation, cosmetics and stress. These build up to a point where our body’s self-regulatory processes break down and chronic disease results.
Follow this page for a list of nutritional and lifestyle interventions you can follow to regain your health (prior to supplements for undermethylation if needed). #methylation #undermethylation #biochemistry #health #wellness #fitness #healthy #lifestyle #dna #energy #hormones #immunesystem #detox #detoxification #mood #psychology #mentalhealth #healthbasics #healthylife #healthymind #healthybody #waterfall
Choose as many active outdoor activities as possible.
The added bonus of keeping in shape, in my humble opinion, is appreciating nature and experiencing far more that your chosen destination has to offer.
- Walk around the city for a couple of hours
- 30 min morning stretch followed by a 2-3 hour trek through a national park
- 1-3 hour surf
- 2 hr rockclimb
- 10 X 40m beach sprints
- 1.5hr coastal rock hopping
- Ocean swim
- Stand-up paddleboard
- Dance class or go out clubbing all night!
"Keeping an active mind has been vital to survival."